Output will be added here as the project progresses.

Published journal articles

  1. Van der Laan KWF, Reesink KD, Van der Bruggen MM, Jaminon AMG, Schurgers LJ, Megens RTA, Huberts WH, Delhaas T, Spronck B: Improved quantification of arterial wall cell density by a nucleus splitting approach applied to 3D two-photon laser-scanning microscopy recordings. Frontiers in Physiology 2021 [in press]. Link.
  2. Giudici A, Spronck B: A first step towards recognising the fundamental role of smooth muscle tone in large artery (dys)function? Journal of Hypertension 2021 [in press]. Link.
  3. Malik AEF, Delhaas T, Spronck B, Henry RMA, Joseph J, Stehouwer CDA, Mess WH, Reesink KD: Single M-Line Can be Used for Carotid Stiffness Screening as Reliably as Multi M-line – The Maastricht Study. Frontiers in Physiology 2021; 12:787083. Link.
  4. Spronck B, Obeid MJ, Paravathaneni M, Gadela NV, Singh G, Magro CA, Kulkarni V, Kondaveety S, Gade KC, Bhuva R, Kulick-Soper CM, Sanchez N, Akers S, Chirinos JA: Predictive Ability of Blood Pressure-Corrected Arterial Stiffness Indices: A Comparison of Pulse Wave Velocity, Cardio-Ankle Vascular Index (CAVI), and CAVI0. American Journal of Hypertension 2021 [in press]. Link.
  5. Caescu CI, Hansen J, Xiao W, Arnaud P, Spronck B, Hashimoto T, Murtada S-I, Borkar R, Humphrey JD, Gallo JM, Jondeau G, Boileau C, Iyengar R, He JC, Ramirez F: Inhibition of the multifunctional homeodomain-interacting protein kinase 2 (HIPK2) alleviates thoracic aortic disease in mice with progressively severe Marfan syndrome. Arteriosclerosis, Thrombosis and Vascular Biology 2021; 41:2483–2493. Link.
  6. Spronck B, Latorre M, Wang M, Mehta S, Caulk AW, Ren P, Ramachandra AB, Murtada S-I, Rojas A, He C-S, Jiang B, Bersi MR, Tellides G, Humphrey JD: Excessive Adventitial Stress Drives Inflammation-Mediated Fibrosis in Hypertensive Aortic Remodeling in Mice. Journal of the Royal Society Interface 2021; 18:20210336. Link.
  7. Parikh S, Ganizada B, Debeij G, Natour E, Maessen J, Spronck B, Schurgers L, Delhaas T, Huberts W, Bidar E, Reesink KD: Intra-operative video-based measurement of biaxial strains of the ascending thoracic aorta. Biomedicines 2021; 9:670. Link.
  8. Van der Bruggen MM, Spronck B, Delhaas T, Reesink KD,* Schalkwijk CG:* The putative role of methylglyoxal in arterial stiffening. Heart, Lung & Circulation 2021; 30:1681-1693. Link.
  9. Giudici A, Khir AW, Reesink KD, Delhaas T, Spronck B: Five years of cardio-ankle vascular index (CAVI) and CAVI0: How close are we to a pressure-independent index of arterial stiffness? Journal of Hypertension 2021; 39:2128-2138. Link.
  10. Spronck B: Disentangling arterial stiffness and blood pressure. Heart, Lung & Circulation 2021; 30:1599-1601. Link.
  11. Giudici A, Khir AW, Szafron JM, Spronck B: From uniaxial testing of isolated arterial layers to a tri-layered arterial wall: A novel constitutive modelling framework. Annals of Biomedical Engineering 2021; 49:2454-2467. Link.
  12. Van der Bruggen M,* Spronck B,* Bos S, Heusinkveld MHG, Taddei S, Ghiadoni L, Delhaas T, Bruno RM, Reesink KD: Pressure-corrected carotid stiffness and Young’s modulus: Evaluation in an outpatient clinic setting. American Journal of Hypertension 2021; 34:737–743. Link.
  13. Van der Bruggen M, Reesink KD, Spronck PJM, Bitsch N, Hameleers J, Megens RTA, Schalkwijk CG, Delhaas T, Spronck B: An integrated set-up for ex vivo characterisation of biaxial murine artery biomechanics under pulsatile conditions. Scientific Reports 2021; 11:2671. Link.
  14. Bruno RM, Spronck B, Hughes A, Lacolley P, Mayer C, Muiesan ML, Rajkumar C, Terentes-Printzios D, Weber T, Willum Hansen T, Boutouyrie P: Covid-19 effects on ARTErial StIffness and vascular AgeiNg: CARTESIAN study protocol. Artery Research 2021; 27:59-68. Link.
  15. Spronck B, Tan I, Reesink KD, Georgevsky D, Delhaas T, Avolio AP, Butlin M: Heart rate and blood pressure dependence of aortic distensibility in rats: Comparison of measured and calculated pulse wave velocity. Journal of Hypertension 2021; 39:117–126. Link.
  16. Pucci G, Spronck B, Avolio AP, Vaudo G, Anastasio F, Van den Meiracker AH, Mattace-Raso FUS: Age-specific acute changes in carotid-femoral pulse wave velocity during head-up tilting. American Journal of Hypertension 2020; 33:1112–1118. Link.
  17. Zanoli L, Briet M, Empana JP, Cunha PG, Mäki-Petäjä KM, Protogerou AD, Tedgui AT, Touyz RM, Schiffrin E, Spronck B, Bouchard P, Vlachopoulos C, Bruno RM, Boutouyrie P: Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society. Journal of Hypertension 2020; 38:1682–1698. Link.
  18. Spronck B, Jurko A, Mestanik M, Avolio AP, Tonhajzerova I. Reply to Comments: Using the Cardio-Ankle Vascular Index (CAVI) or the Mathematical Correction Form (CAVI0) in Clinical Practice. International Journal of Molecular Sciences 2020; 21:2647. Link
  19. Cooke AB, Dasgupta K, Spronck B, Sharman JE, Daskalopoulou SS. Adults with Type 2 Diabetes Exhibit a Greater Exercise-Induced Increase in Arterial Stiffness and Vessel Hemodynamics. Hypertension 2020; 75:1565–1573. Link.
  20. Butlin M, Tan I, Spronck B, Avolio AP: Measuring arterial stiffness in animal experimental studies. Arteriosclerosis, Thrombosis and Vascular Biology 2020; 40:1068-1077. Link.
  21. Spronck B,* Ferruzzi J,* Bellini C, Caulk AW, Murtada S-I, Humphrey JD: Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging. Journal of Hypertension 2020; 38:1312–1321. Link.
  22. Mestanik M, Olexova LB, Jurko Jr A, Spronck B, Jurko T, Mestanikova A, Visnovcova Z, Sekaninova N, Kudela E, Tonhajzerova I: Novel biomarkers of early atherosclerotic changes for personalised prevention of cardiovascular disease in cervical cancer and human papillomavirus infection. International Journal of Molecular Sciences 2019; 20:3720. Link.
  23. Reesink KD, Spronck B: Constitutive interpretation of arterial stiffness in clinical studies – a methodological review. American Journal of Physiology – Heart and Circulatory Physiology 2019; 316:H693-H709A. Link.
  24. Spronck B, Humphrey JD: Arterial Stiffness: Different Metrics, Different Meanings. Journal of Biomechanical Engineering 2019 [in press]. Link.
  25. Spronck B, Mestanik M, Tonhajzerova I, Jurko A, Tan I, Butlin M, Avolio AP: Easy conversion of cardio-ankle vascular index into CAVI0: influence of scale coefficients. Journal of Hypertension 2019; 37:1913-1914. Link.
  26. Hansen J, Galatioto J, Caescu CI, Arnaud P, Calizo R, Spronck B, Murtada SI, Borkar RM, Weinberg A, Azeloglu EU, Bintanel-Morcillo M, Gallo JM, Humphrey JD, Jondeau G, Boileau C, Ramirez F, Iyengar R: Common subcellular mechanisms between afflicted patients and mutant mice identify a new drug treatment for aortic aneurysm in Marfan syndrome. Journal of Clinical Investigation Insight 2019. Link.

*Authors contributed equally.

Published preprints

  1. Spronck B, Caulk AW, Ramachandra AB, Murtada S-I, Rojas A, He C-S, Bersi MR, Tellides G, Humphrey JD: Genetic background dominates fibrotic aortic remodeling during angiotensin-induced hypertension in mice. bioRxiv, DOI 10.1101/727800. Link.

Conference presentations

  1. Van der Bruggen M, Reesink KD, Spronck PJM, Bitsch N, Hameleers J, Megens RTA, Schalkwijk CG, Delhaas T, Spronck B: In-Vitro Characterization of Mouse Carotid Artery Mechanics by Dynamic Biaxial Pressure -Myography. 29th European Meeting on Hypertension & Cardiovascular Protection (Oral presentation, June 21 – 24, 2019, Milan, Italy). Link to abstract.
  2. Van der Bruggen M, Reesink KD, Spronck PJM, Bitsch N, Hameleers J, Megens RTA, Schalkwijk CG, Delhaas T, Spronck B: In-Vitro Characterization of Mouse Carotid Artery Mechanics by Dynamic Biaxial Pressure -Myography. European Microcirculation and Vascular Biology Congress (Poster presentation, April 15 – 18, Maastricht, the Netherlands).
  3. Spronck B, Ferruzzi J, Humphrey JD: Modest arterial remodeling in male and female fibulin-5 knock-out mice in response to induced hypertension. 29th European Meeting on Hypertension & Cardiovascular Protection (Oral presentation, June 21 – 24, 2019, Milan, Italy). Link to abstract.
  4. Spronck B, Ramachandra AB, Toczek J, Han J, Sadeghi MM, Humphrey JD: Knock-out of matrix metalloproteinase-12 exacerbates compromised mechanical homeostasis in arterial aging. Artery 18 (Oral presentation, October 18 – 20, 2018, Guimarães, Portugal). Link.