Output

Work directly using DynamX set-ups or their data

  1. Neutel CHG,* Van der Laan KWF,* Wesley CD, Krüger DN, Pencheva MG, Schalkwijk CG, De Meyer GRY, Martinet W, Delhaas T, Reesink KD, Giudici A, Guns PJ,# Spronck B:# The MAASWERP study: An international, comparative case study on measuring aortic biomechanics of the aged murine aorta. Pulse (Basel) 2024 [in press]. Link.
  2. Van der Laan KWF, Reesink KD, Lambrichts S, Bitsch NJJE, Van der Taelen L, Foulquier S, Delhaas T, Spronck B, Giudici A: Effect of rapid cooling, frozen storage, and thawing on the passive viscoelastic properties and structure of the rat aorta. Journal of Biomechanics 2024; 171:112190. Link.
  3. Giudici A, Van der Laan KWF, Van der Bruggen MM, Parikh S, Berends E, Foulquier S, Delhaas T, Reesink KD, Spronck B: Constituent-based quasi-linear viscoelasticity: A revised quasi-linear modelling framework to capture non-linear viscoelasticity in arteries. Biomechanics and Modeling in Mechanobiology 2023; 22:1607–1623. Link.
  4. Van der Laan KWF, Reesink KD, Van der Bruggen MM, Jaminon AMG, Schurgers LJ, Megens RTA, Huberts WH, Delhaas T, Spronck B: Improved quantification of arterial wall cell density by a nucleus splitting approach applied to 3D two-photon laser-scanning microscopy recordings. Frontiers in Physiology 2022; 12:814434. Link.
  5. Van der Bruggen M, Reesink KD, Spronck PJM, Bitsch N, Hameleers J, Megens RTA, Schalkwijk CG, Delhaas T, Spronck B: An integrated set-up for ex vivo characterisation of biaxial murine artery biomechanics under pulsatile conditions. Scientific Reports 2021; 11:2671. Link.
  6. Spronck B: Stiff vessels approached in a flexible way: Advancing quantification and interpretation of arterial stiffness. PhD thesis, Maastricht University. Link.

Related work (partly) funded by DynamX grants

  1. Cavinato C, Spronck B, Caulk AW, Murtada S-I, Humphrey JD: AT1b Receptors Contribute to Regional Disparities in Angiotensin II Mediated Aortic Remodeling in Mice. Journal of the Royal Society Interface 2024; 21:20240110.
  2. Giudici A,* Szafron JM,* Ramachandra AB, Spronck B: Instability in computational models of vascular smooth muscle cell contraction. Annals of Biomedical Engineering 2024; 52:2403-2416.
  3. Niestrawska JA,* Spronck B,* Cavinato C, Humphrey JD: Tempol improves aortic mechanics in a mouse model of hypertension. Journal of Biomechanics 2024; 162:111911.
  4. Spronck B, Terentes-Printzios D, Avolio AP, Boutouyrie P, Guala A, Jerončić A, Laurent S, Barbosa ECD, Baulmann J, Chen CH, Chirinos J, Daskalopoulou SS, Hughes AD, Mahmud A, Mayer CC, Park JB, Pierce GL, Schutte AE, Urbina EM, Wilkinson IB, Segers P, Sharman JE, Tan I, Vlachopoulos C, Weber T, Bianchini E, Bruno RM: 2024 Recommendations for Validation of Noninvasive Arterial Pulse Wave Velocity Measurement Devices. Hypertension 2024; 81:183–192.
  5. Giudici A, Spronck B, Wilkinson IB, Khir AW: Tri-layered constitutive modelling unveils functional differences between swine ascending and descending thoracic aorta. Journal of the Mechanical Behavior of Biomedical Materials 2023; 141:105752
  6. Salarian M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra AB, Gim M, Jung J-J, Kukreja G, Lakerheram D, Kim S-K, Humphrey JD, Sadeghi MM: Homeostatic, non-canonical role of macrophage elastase in vascular integrity. Circulation Research 2023; 132:432–448.
  7. Malik AEF, Giudici A, Van der Laan KWF, Op ’t Roodt J, Mess WH, Delhaas T, Spronck B, Reesink KD: Detectable bias between vascular ultrasound echo-tracking systems: relevance depends on application. Journal of Clinical Medicine 2022; 12:69.
  8. Zhang E, Spronck B, Humphrey JD, Karniadakis GE: G2Φnet: relating genotype and biomechanical phenotype of tissues with deep learning. PLOS Computational Biology 2022; 18:e1010660.
  9. Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Salarian M, Sadeghi MM, Humphrey JD: Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal of Biomechanics 2022; 141:111179.
  10. Athaide CE, Spronck B, Au JS: Physiological basis for longitudinal motion of the arterial wall. American Journal of Physiology – Heart and Circulatory Physiology 2022; 322:H689-H701.
  11. Giudici A, Spronck B: The role of layer-specific residual deformations in arterial mechanics: Analysis via a novel modelling framework. Artery Research 2022; 28:41–54.
  12. Giudici A, Spronck B: A first step towards recognising the fundamental role of smooth muscle tone in large artery (dys)function? Journal of Hypertension 2021 [in press]. Link.
  13. Malik AEF, Delhaas T, Spronck B, Henry RMA, Joseph J, Stehouwer CDA, Mess WH, Reesink KD: Single M-Line Can be Used for Carotid Stiffness Screening as Reliably as Multi M-line – The Maastricht Study. Frontiers in Physiology 2021; 12:787083. Link.
  14. Spronck B, Obeid MJ, Paravathaneni M, Gadela NV, Singh G, Magro CA, Kulkarni V, Kondaveety S, Gade KC, Bhuva R, Kulick-Soper CM, Sanchez N, Akers S, Chirinos JA: Predictive Ability of Blood Pressure-Corrected Arterial Stiffness Indices: A Comparison of Pulse Wave Velocity, Cardio-Ankle Vascular Index (CAVI), and CAVI0. American Journal of Hypertension 2021 [in press]. Link.
  15. Caescu CI, Hansen J, Xiao W, Arnaud P, Spronck B, Hashimoto T, Murtada S-I, Borkar R, Humphrey JD, Gallo JM, Jondeau G, Boileau C, Iyengar R, He JC, Ramirez F: Inhibition of the multifunctional homeodomain-interacting protein kinase 2 (HIPK2) alleviates thoracic aortic disease in mice with progressively severe Marfan syndrome. Arteriosclerosis, Thrombosis and Vascular Biology 2021; 41:2483–2493. Link.
  16. Spronck B, Latorre M, Wang M, Mehta S, Caulk AW, Ren P, Ramachandra AB, Murtada S-I, Rojas A, He C-S, Jiang B, Bersi MR, Tellides G, Humphrey JD: Excessive Adventitial Stress Drives Inflammation-Mediated Fibrosis in Hypertensive Aortic Remodeling in Mice. Journal of the Royal Society Interface 2021; 18:20210336. Link.
  17. Parikh S, Ganizada B, Debeij G, Natour E, Maessen J, Spronck B, Schurgers L, Delhaas T, Huberts W, Bidar E, Reesink KD: Intra-operative video-based measurement of biaxial strains of the ascending thoracic aorta. Biomedicines 2021; 9:670. Link.
  18. Van der Bruggen MM, Spronck B, Delhaas T, Reesink KD,* Schalkwijk CG:* The putative role of methylglyoxal in arterial stiffening. Heart, Lung & Circulation 2021; 30:1681-1693. Link.
  19. Giudici A, Khir AW, Reesink KD, Delhaas T, Spronck B: Five years of cardio-ankle vascular index (CAVI) and CAVI0: How close are we to a pressure-independent index of arterial stiffness? Journal of Hypertension 2021; 39:2128-2138. Link.
  20. Spronck B: Disentangling arterial stiffness and blood pressure. Heart, Lung & Circulation 2021; 30:1599-1601. Link.
  21. Giudici A, Khir AW, Szafron JM, Spronck B: From uniaxial testing of isolated arterial layers to a tri-layered arterial wall: A novel constitutive modelling framework. Annals of Biomedical Engineering 2021; 49:2454-2467. Link.
  22. Van der Bruggen M,* Spronck B,* Bos S, Heusinkveld MHG, Taddei S, Ghiadoni L, Delhaas T, Bruno RM, Reesink KD: Pressure-corrected carotid stiffness and Young’s modulus: Evaluation in an outpatient clinic setting. American Journal of Hypertension 2021; 34:737–743. Link.
  23. Bruno RM, Spronck B, Hughes A, Lacolley P, Mayer C, Muiesan ML, Rajkumar C, Terentes-Printzios D, Weber T, Willum Hansen T, Boutouyrie P: Covid-19 effects on ARTErial StIffness and vascular AgeiNg: CARTESIAN study protocol. Artery Research 2021; 27:59-68. Link.
  24. Spronck B, Tan I, Reesink KD, Georgevsky D, Delhaas T, Avolio AP, Butlin M: Heart rate and blood pressure dependence of aortic distensibility in rats: Comparison of measured and calculated pulse wave velocity. Journal of Hypertension 2021; 39:117–126. Link.
  25. Pucci G, Spronck B, Avolio AP, Vaudo G, Anastasio F, Van den Meiracker AH, Mattace-Raso FUS: Age-specific acute changes in carotid-femoral pulse wave velocity during head-up tilting. American Journal of Hypertension 2020; 33:1112–1118. Link.
  26. Zanoli L, Briet M, Empana JP, Cunha PG, Mäki-Petäjä KM, Protogerou AD, Tedgui AT, Touyz RM, Schiffrin E, Spronck B, Bouchard P, Vlachopoulos C, Bruno RM, Boutouyrie P: Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society. Journal of Hypertension 2020; 38:1682–1698. Link.
  27. Spronck B, Jurko A, Mestanik M, Avolio AP, Tonhajzerova I. Reply to Comments: Using the Cardio-Ankle Vascular Index (CAVI) or the Mathematical Correction Form (CAVI0) in Clinical Practice. International Journal of Molecular Sciences 2020; 21:2647. Link
  28. Cooke AB, Dasgupta K, Spronck B, Sharman JE, Daskalopoulou SS. Adults with Type 2 Diabetes Exhibit a Greater Exercise-Induced Increase in Arterial Stiffness and Vessel Hemodynamics. Hypertension 2020; 75:1565–1573. Link.
  29. Butlin M, Tan I, Spronck B, Avolio AP: Measuring arterial stiffness in animal experimental studies. Arteriosclerosis, Thrombosis and Vascular Biology 2020; 40:1068-1077. Link.
  30. Spronck B,* Ferruzzi J,* Bellini C, Caulk AW, Murtada S-I, Humphrey JD: Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging. Journal of Hypertension 2020; 38:1312–1321. Link.
  31. Mestanik M, Olexova LB, Jurko Jr A, Spronck B, Jurko T, Mestanikova A, Visnovcova Z, Sekaninova N, Kudela E, Tonhajzerova I: Novel biomarkers of early atherosclerotic changes for personalised prevention of cardiovascular disease in cervical cancer and human papillomavirus infection. International Journal of Molecular Sciences 2019; 20:3720. Link.
  32. Reesink KD, Spronck B: Constitutive interpretation of arterial stiffness in clinical studies – a methodological review. American Journal of Physiology – Heart and Circulatory Physiology 2019; 316:H693-H709A. Link.
  33. Spronck B, Humphrey JD: Arterial Stiffness: Different Metrics, Different Meanings. Journal of Biomechanical Engineering 2019 [in press]. Link.
  34. Spronck B, Mestanik M, Tonhajzerova I, Jurko A, Tan I, Butlin M, Avolio AP: Easy conversion of cardio-ankle vascular index into CAVI0: influence of scale coefficients. Journal of Hypertension 2019; 37:1913-1914. Link.
  35. Hansen J, Galatioto J, Caescu CI, Arnaud P, Calizo R, Spronck B, Murtada SI, Borkar RM, Weinberg A, Azeloglu EU, Bintanel-Morcillo M, Gallo JM, Humphrey JD, Jondeau G, Boileau C, Ramirez F, Iyengar R: Common subcellular mechanisms between afflicted patients and mutant mice identify a new drug treatment for aortic aneurysm in Marfan syndrome. Journal of Clinical Investigation Insight 2019. Link.

*Authors contributed equally.